Effects of curcumin supplementation on the severity of intra-abdominal adhesions in rats

Kono, Pedro AfonsoGonçalves Junior, RivairKoga, Adriana YurikoSantos, Melquesedeque dosSalina, Matheus Von JelitaDalazoana Filho, ElderToledo Junior, AlceuLipinski, Leandro CavalcanteRodrigues, Marcos Ricardo da SilvaCampos, Eurico Cleto Ribeiro de

ABSTRACT Purpose: To evaluate the effect of curcumin administered by gavage, on reducing intra-abdominal adhesions and attenuating the inflammatory process, assessed by a serum marker. Methods: Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The curcumin group received curcumin by gavage at the dose of 200 mg/kg over the seven days preceding and the seven days following surgery. In the control group, an isovolumetric administration of 0.9% saline solution was given by gavage. Both groups underwent a median laparotomy and left-sided colotomy. On the eighth postoperative day, the animals were euthanized for intracavitary adhesion analysis and left colon resection for histological examination. Intra-abdominal adhesions were classified from grade 0 to 4 based on increases in number, intensity, and ease of lysis. Results: Curcumin administration did not significantly reduce the severity of intra-abdominal adhesions (p = 0.7143) nor the severity of colonic inflammatory infiltration. However, a significant reduction in C-reactive protein levels was observed preoperatively in the curcumin group (p 0.05). Conclusion: While curcumin was not able to reduce the severity of intra-abdominal adhesions, it demonstrated the ability to attenuate the inflammatory process associated with the surgical procedure.

1. Disease Models, Animal
2. Inflammation
3. Tissue Adhesions
4. General Surgery
5. Curcumin