Genetic variability of bovine viral diarrhea virus in the 5-utr in the central anatolia of Turkey
Sarikaya, BakiKürat Azkur, AhmetGazyagci, SerkalEren Aslan, Muhammet
Background: The genus Pestivirus in the family Flaviviridae comprises the members bovine viral diarrhea virus type 1 (BVDV-1), classical swine fever virus and border disease virus. The BVDV enveloped and the genome is a single-strand positive sense RNA molecule of approximately 12.3 kilobases in length. The genome is transcribed as a single open reading frame, fl anked by 5 and 3 untranslated regions. Genetic typing of BVDV has usually been performed using sequences from the 5-UTR, Npro and E2 regions. BVDV is an RNA virus with a high genome variability having practical consequences on epidemiology, diagnosis and disease control. Genetic monitoring was suggested as the fi rst step in BVDV control because genetic typing of BVDV shows evidence of an increasing number of variants. For this reason circulating genetic typing of BVDV is important update these data. Circulating BVDV in the fi eld shows genetic and antigenic diversity. 5-UTR nucleotide sequence analysis has been widely used for pestivirus genotype identifi cation. To further characterize the BVDV, the nucleotide sequence of the 5-UTR that represents a conserved region of the virus genome was analyzed in many studies. The purpose of the current study was to investigate genotypes of pestivirus were circulating in cattle populations in Central Anatolia Region of Turkey.Materials, Methods & Results: Blood samples
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