Angiogenic factors and ovarian follicle development

Bruno, J BMatos, M H TChaves, R NCelestino, J J HSaraiva, M V ALima-Verde, I BAraújo, V RFiqueiredo, J R

Ovarian follicles require an adequate blood supply for oxygen, nutrients and hormones, in addition to eliminating CO2 and other metabolites. Acquisition of an adequate vascular supply is probably a limiting step in the selection and maturation of the dominant follicle. In this way, there is a progressive interest in the study of the growth factors involved in the angiogenic process. In addition, a better understanding about the mechanisms that regulate the expression and action of these factors could be a key point to increase the reproductive performance in females. Therefore, this review aims to summarize current data on the importance of the pro- and anti-angiogenic growth factors which regulate angiogenesis in ovarian follicle development.(AU)

1. angiogenesis
2. growth factors
3. ovary
4. follicle